Janssen Infectious Diseases Discovery is focusing increasingly on host response mechanisms, from improved immune control of chronic infections (HBV), activation of latent virus in immune cells (HIV) to control of excessive immune response with acute infections (respiratory viruses). This increased focus relies also on our ability to identify rate-limiting mechanisms of host response that are tractable in terms of compound selection and optimization and/or in terms of efficacy response modeling in preclinical and clinical studies. Since host response implies the orchestration of multiple effector functions from diverse immune cells through cross-cell signaling networks, there is a clear need for scientific competencies in host response to viral pathogens that combine a broad knowledge of immune cell functionalities and of dysfunction in disease with the ability of experimental derivation of mechanisms and biomarkers from hypotheses derived from high-dimensional, 'systems immunology' exploratory approaches.
The candidate will introduce a combination of systems immunology methodology and strong expertise in hypothesis-driven experimental validation to identify tractable cellular and molecular mechanisms of host response modulation that will lead to the identification of new, impactful therapeutics and informative biomarkers for host-pathogen disease states.
His/her broad scientific knowledge base in the major components and interfaces of the innate & adaptive host response will guide internal discovery and biomarker teams and collaborating external groups on the most effective systems/experimental immunology research plans with clear decision points.
His/her impact will be through a combination of direct people management, leading discovery (sub) team, or lead as an individual contributor in the scientific decision making of the senior leadership and in the coaching/teaching of junior scientists in systems/experimental immunology.
He/she will evolve a network of outside expertise in relevant state-of-the art pathogen-host response systems immunology, also driven by the scientific excellence of his input when participating in collaborations/consortia in the field and in the production of impactful publications in the field.
PhD or MD/PhD in Immunology or related field. Several years (6 ) of postgraduate experience.
Clear evidence from publications of the ability to significantly contribute to the field of immunology at the interface between innate and adaptive immunity and between systems approaches and experimental hypothesis testing.
Demonstrated capacity to obtain competitive funding in an academic environment and/ identify, defend and implement new and programs in an industrial setting.
Industrial experience also in the setting of academic collaboration with industry is a plus.
Demonstrated capacity for people management/team leadership/effectiveness in a matrixed environment
Careerbuilder.be - 9 months ago
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